Mildronate 60 capsules. 500 mg blister
Dosage form: caps. 500 mg blister
Package quantity: 60
Manufacturer: Grindeks (Latvia)
Mildronat restores the equilibrium processes of oxygen delivery and consumption in cells, prevents the violation of transport ATP simultaneously activates glycolysis, which occurs without any additional consumption of oxygen.
As a result of lower concentrations of carnitine is synthesized hard γ-butyrobetaine, which has vasodilator properties.
The mechanism of action of Mildronate defines a wide range of its pharmacological effects.It increases stamina, reduces symptoms of mental and physical stress.
The drug has a pronounced cardioprotective effect. In heart failure, it improves contractive ability of myocardium, increases tolerance to physical load. In stable angina II and III functional class increases physical performance of patients and reduces the frequency of angina attacks.
In acute and chronic ischemic cerebrovascular disorders Mildronat improves blood circulation in the ischemic focus, contributing to the redistribution of cerebral blood flow in favor of ischemic area.
The inflammation also possess a tonic effect on the Central nervous system, it eliminates functional disturbances of somatic and autonomic nervous system, including in abstinent syndrome in patients with chronic alcoholism. The drug also has a positive effect on dystrophic altered retinal blood vessels and cellular immunity.
Pharmacokinetics: After oral administration the drug is rapidly absorbed from the gastrointestinal tract. Its bioavailability is 78%. The maximum concentration in plasma achieved through 1-2 hours after administration. The half-life is 3-6 hours.
Indications: therapy of ischemic heart disease (angina, myocardial infarction, congestive heart failure, and dyshormonal cardiomyopathy); acute and chronic disorders of brain blood supply (cerebral strokes, and chronic insufficiency of cerebral circulation); hemophthalmus and bleeding in the retina of different etiology, thrombosis Central retinal vein and its branches, retinopathy of different etiology (diabetic, hypertensive); decreased performance, physical overload, including athletes; withdrawal syndrome in chronic alcoholism (in combination with specific alcoholism therapy).
The USE of Mildronate capsules. 500 mg. № 60: adults inside.
1. Cardiovascular disease. In the composition Mildronat capsules. 500mg. № sixtieth complex therapy - 0,5-1,0 g / day at a time (or divide the daily dose into 2 doses). The course of treatment - 4-6 weeks.
Cardialgia on background dyshormonal myocardial dystrophy - inside of 0.5 g per day per single dose (or divided into 2 doses). The course of treatment - 12 days.
2. Violation of cerebral circulation. Acute phase - 0.5-1.0 g per day per single dose or divided into 2 doses. The total course of treatment - 4-6 weeks.
Chronic disorders - 0.5 g orally per day per single dose (or divided into 2 doses).The total course of treatment - 4-6 weeks.
Repeated courses (usually 2-3 times a year) is possible after consultation with the doctor.
3. Vascular pathology and dystrophic diseases of the retina. Use the injectable form of the drug.
4. Mental and physical overload, including athletes. Apply
0.5 g 2 times a day. The course of treatment is 10-14 days. If necessary, repeat the treatment after 2-3 weeks.
Athletes prescribed at 0.5-1.0 g orally 2 times daily, before training.The duration of the course during the preparatory period - 14-21 days, during the period of competition - 10-14 days.
5. Chronic alcoholism. 0.5 g 4 times a day. The course of treatment - 7-10 days.
Side effect: In rare cases - itching, dyspeptic phenomena, tachycardia, agitation, changes in blood pressure, mainly towards hypotension.
Contraindications: Hypersensitivity to the drug.
Increased intracranial pressure (in case of violation of venous outflow in intracranial tumors). The age of 12.
Overdose: Possible abrupt changes in blood pressure. In this case, apply the necessary medicines.
Application features: use With caution in chronic diseases of the liver and kidneys.
There are insufficient data on the use of Mildronate in children.
The safety of the drug in pregnancy has not been proven. In order to avoid possible adverse effects on the fetus during pregnancy, it is not prescribed.
Not defined, selects whether the drug is mother's milk. If the treatment with Mildronate mother really necessary, breast-feeding is stopped.
The possible development of stimulating effect it is recommended to apply Mildronat in the first half of the day.
Interaction with other medicinal products: The drug can be combined with antianginal agents, anticoagulants and antiplatelet agents, anti-arrhythmic means, the cardiac glycosides, diuretics and other drugs.
Inflammation can potentiate the action of nitroglycerin, nifedipine, alpha-blockers, antihypertensive drugs and peripheral vasodilators.
Terms and conditions storage: Store at temperature not exceeding 25 ° C and out of reach of children. Shelf life - 4 years.