The active substances of the Neurorubin preparation are thiamine hydrochloride (vitamin B1), pyridoxine hydrochloride (vitamin B6), cyanocobalamin (vitamin B12).
Neurorubin is a combined multivitamin preparation, which includes high doses of three vitamins: B1, B6, B12, which play an important role in the functioning of the nervous system. Each of these vitamins is needed to ensure optimal metabolism in nerve cells. Drinking high doses of these vitamins has an analgesic effect.
B vitamins are components of enzyme systems that regulate the metabolism of proteins, fats and carbohydrates.
lesions of the facial nerve;
radicular neuritis due to degenerative diseases of the spine;
inflammation of the sciatic nerve.
Neurorubin injection for 3 ml No. 5 in ampoules.
Neurorubin forte lactab tablets, film-coated No. 20 (10x2) in blisters.
Mode of application
Neurorubin injection is used for intramuscular injection.
In severe cases - 1 ampoule per day until acute symptoms are eliminated. After reducing the severity of symptoms or in case of moderate severity - 1 to 3 times a week. The duration of treatment depends on the nature and severity of the disease.
To maintain injection therapy or to prevent relapse, it is recommended to use neurorubin in tablet form.
Neurorubin tablets are administered orally before or during a meal without chewing, with plenty of water. The usual dose for adults is 1 to 2 tablets per day. The course of treatment is 4 weeks. Treatment may be extended at the discretion of the physician.
Children should not be prescribed the drug, since there is no experience with pediatric use.
Use during pregnancy or lactation
Neurorubin can be prescribed only after a careful assessment of the relationship between the benefits to the mother and the risk to the fetus, since there is insufficient data on the safety of the drug during pregnancy.
Breastfeeding should be discontinued while taking the drug.
As a result of the patient's hypersensitivity to vitamins B1, B6 and B12 during treatment, reactions from the skin and subcutaneous tissue may occur.
Drinking alcohol and black tea reduces the absorption of vitamin B1.
Drinking drinks containing sulfites, such as wine, enhances the dehydration of vitamin B1.
Neurorubin should not be taken with a severe or acute form of decompensation of cardiac activity and angina pectoris.
Since Neurorubin contains vitamin B6, it should be used with caution in patients with a history of gastric and duodenal ulcer, expressed by impaired renal and hepatic function.
Pyridoxine can provoke the occurrence of acne or acne, or increase the severity of existing ones.
Neurorubin injection is not recommended for intravenous administration.
Intramuscular injections of vitamin B12 can trigger an anaphylactic reaction in patients with hypersensitivity.
Parenteral administration of vitamin B12 may temporarily affect the diagnosis of funicular myelosis or pernicious anemia.
Neurorubin is contraindicated in case of hypersensitivity to any of the components of the drug.
Vitamin B1 is contraindicated in allergic diseases.
Vitamin B6 is contraindicated in peptic ulcer of the stomach and duodenum during exacerbation.
Vitamin B12 is contraindicated in erythremia, erythrocytosis, thromboembolism.
When using Neurorubin, the following adverse reactions are possible:
hypersensitivity reactions, including anaphylactic shock;
inhibition of prolactin secretion;
anxiety, nervous agitation, headache, dizziness;
cyanosis, pulmonary edema, mainly in patients with hypersensitivity;
gastrointestinal upsets, vomiting, abdominal pain, increased acidity of gastric juice;
worsening acne or its appearance.
Interaction with other drugs and other types of interaction
Admission of neurorubin may increase the toxicity of isoniazid.
Antacids, alcohol and tea slow down the absorption of vitamin B1.
Admission of Neurorubin may reduce the effectiveness of the anti-Parkinsonian effect of levodopa.
Loop diuretics, for example, furosemide, inhibiting tubular reabsorption, with prolonged use can increase the excretion of thiamine and, therefore, reduce its level.
The ability to influence the reaction rate when driving vehicles or other mechanisms
When using the drug Neurorubin in recommended doses, it does not affect the ability to drive vehicles and other mechanisms.
If dizziness is observed during treatment, one should refrain from driving vehicles and working with mechanisms.
An overdose of Neurorubin causes an increase in side effects.
Vitamin B1: causes muscle relaxation, suppresses the conduction of nerve impulses.
Vitamin B6: has a very low toxicity. Excessive use of high doses of Vitamin B6 for several months can lead to neurotoxicity, cerebral seizures, very rarely - seborrheic dermatitis and hypochromic anemia.
Vitamin B12: with parenteral administration of high doses, it can provoke eczematous skin disorders and benign forms of acne.
In case of an overdose, gastric lavage and administration of enterosorbents are indicated.